Long COVID Long COVID, also known as post-acute sequelae of SARS-CoV-2 infection (PASC) or post-acute sequelae of COVID-19 (PASC-19), refers to the persistence of symptoms following acute COVID-19 infection. These symptoms can range from mild to severe, and can include fatigue, brain fog, shortness of breath, chest pain, and heart palpitations. Diagnosis of Long COVID